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Preferred Term:

CXCR3 receptor

CD183 is a G protein-coupled receptor with selectivity for three chemokines, termed IP10 (interferon-g-inducible 10 kDa protein), Mig (monokine induced by interferon-g) and I-TAC (interferon-inducible T cell a-chemoattractant). Binding of chemokines to CD183 induces cellular responses that are involved in leukocyte traffic, most notably integrin activation, cytoskeletal changes and chemotactic migration. Inhibition by Bordetella pertussis toxin suggests that heterotrimeric G protein of the Gi-subclass couple to CD183. A hallmark of CD183 is its prominent expression in in vitro cultured effector/memory T cells, and in T cells present in many types of inflamed tissues. In addition, IP10, Mig and I-TAC are commonly produced by local cells in inflammatory lesion, suggesting that CD183 and its chemokines participate in the recruitment of inflammatory cells.
Concept Schemes:
Broader Concept:
Entry Terms:
  • C-X-C chemokine receptor type 3
  • MIG-R (Mig receptor)
  • CD183 antigen
  • chemokine (C-X-C) receptor 3
  • CKR-L2
  • GPR9 (G-protein coupled receptor 9)
  • CXCR3-B
  • interferon-inducible protein 10 receptor
  • chemokine (C-X-C motif) receptor 3
  • CXC chemokine receptor 3
  • IP-10 receptor
  • CXCR3-A
  • CMKAR3
  • I-TAC receptor
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RDF/XMLCreated 2015-03-10, last modified 2015-11-16