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NAL Agricultural Thesaurus
U.S. Department of Agriculture
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Concept Breadcrumbs

Research, Technology, Methods > research > animal research > chemical substances > biochemical compounds > amino acids, peptides and proteins > proteins > receptors > immunologic receptors > cytokine receptors > chemokine receptors > CXCR3 receptor
Fields of Study > biochemistry > biochemical compounds > amino acids, peptides and proteins > proteins > receptors > immunologic receptors > cytokine receptors > chemokine receptors > CXCR3 receptor
Research, Technology, Methods > research > animal research > chemical substances > biochemical compounds > amino acids, peptides and proteins > proteins > membrane proteins > immunologic receptors > cytokine receptors > chemokine receptors > CXCR3 receptor
Fields of Study > biochemistry > biochemical compounds > amino acids, peptides and proteins > proteins > membrane proteins > immunologic receptors > cytokine receptors > chemokine receptors > CXCR3 receptor
Research, Technology, Methods > research > animal research > chemical substances > biochemical compounds > amino acids, peptides and proteins > proteins > receptors > G-protein coupled receptors > chemokine receptors > CXCR3 receptor
Fields of Study > biochemistry > biochemical compounds > amino acids, peptides and proteins > proteins > receptors > G-protein coupled receptors > chemokine receptors > CXCR3 receptor
Research, Technology, Methods > research > animal research > chemical substances > biochemical compounds > amino acids, peptides and proteins > proteins > membrane proteins > G-protein coupled receptors > chemokine receptors > CXCR3 receptor
Fields of Study > biochemistry > biochemical compounds > amino acids, peptides and proteins > proteins > membrane proteins > G-protein coupled receptors > chemokine receptors > CXCR3 receptor
Preferred Term:

receptor CXCR3

Definition:
El antígeno CD183 es un receptor acoplado a la proteína G con selectividad para tres quimiocinas, denominadas proteína 10 inducible por interferón gamma (IP-10), monocina inducida por interferón gamma (MIG) y quimiotaxina alfa de linfocito T inducible por interferón (I-TAC). La unión de las quimiocinas al antígeno CD183 induce respuestas celulares que intervienen en el tránsito de leucocitos y, especialmente, en la activación de integrinas, la activación quimiotáctica y cambios citoesqueléticos. La inhibición mediante Bordetella pertussis sugiere que la proteína G heterotrimérica de la subclase Gi se acopla al antígeno CD183. Una característica distintiva de este antígeno es su prominente expresión en las células T efectoras/de memoria cultivadas in vitro y en las células T presentes en muchos tipos de tejidos inflamados. Además, las quimiocinas IP-10, MIG y I-TAC son producidas comúnmente por células locales en lesiones de naturaleza inflamatoria, lo que indica que el antígeno CD183 y sus quimiocinas participan en la atracción de células inflamatorias.
Concept Schemes:
https://lod.nal.usda.gov/nalt
Términos Genéricos:
receptores de quimiocinas
Términos Relacionados:
URI:
https://lod.nal.usda.gov/nalt/243568
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RDF/XMLCreated 2015-03-10, last modified 2015-11-16