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CXCR5 receptor

This gene was identified as a gene specifically expressed in Burkitt's lymphoma and lymphatic tissues. The protein encoded by this gene is predicted to be a seven transmembrane G protein-coupled receptor and belongs to the CXC chemokine receptor family. BLC, a B-lymphocyte chemoattractant, was identified to be a specific ligand for this receptor. Studies of this gene and its mouse counterpart strongly suggest the essential function of this gene in B cell migration and localization within specific anatomic compartments, such as follicles in lymph nodes as well as in spleen. Two alternatively spliced variants of this gene exist.
Concept Schemes:
Broader Concept:
Entry Terms:
  • chemokine (C-X-C) receptor 5
  • BLR-1 receptor
  • chemokine (C-X-C motif) receptor 5
  • CXC chemokine receptor 5
  • C-X-C chemokine receptor type 5
  • Burkitt lymphoma receptor 1
  • MDR15 receptor
  • CD185 antigen
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RDF/XMLCreated 2015-03-10, last modified 2015-11-16