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CXCR4 receptor

CXCR4 shares features common to G protein coupled receptors. CXCR4 is a receptor for the CXC chemokine PBSF/SDF1 and functions as a co-receptor for HIV-1. CXCR4 is broadly expressed in the immune and the central nervous systems and can mediate migration of resting leukocytes and hematopoietic progenitors in response to SDF1. PBSF/SDF1 and CXCR4 define a signaling system for organ vascularization.
Concept Schemes:
Broader Concept:
Entry Terms:
  • neuropeptide Y receptor Y3
  • chemokine (C-X-C motif) receptor 4
  • LESTR (leukocyte-derived seven transmembrane domain receptor)
  • LPS-associated protein 3
  • fusin
  • CD184 antigen
  • lipopolysaccharide-associated protein 3
  • SDF-1 (stromal cell-derived factor 1 receptor)
  • chemokine (C-X-C) receptor 4
  • seven-transmembrane-segment receptor, spleen
  • LAP-3 protein
  • C-X-C chemokine receptor type 4
  • SDF1-PBSF receptor
  • PSSF receptor (pre-B cell growth-stimulating factor receptor)
  • CXC chemokine receptor 4
  • SDF-1 receptor
  • LESTR receptor
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RDF/XMLCreated 2015-03-10, last modified 2015-11-16