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Preferred Term:

vascular endothelial growth factor A

Definition:
The original member of the family of endothelial cell growth factors referred to as vascular endothelial growth factors. Vascular endothelial growth factor-A was originally isolated from tumor cells and referred to as "tumor angiogenesis factor" and "vascular permeability factor". Although expressed at high levels in certain tumor-derived cells it is produced by a wide variety of cell types. In addition to stimulating vascular growth and vascular permeability it may play a role in stimulating vasodilation via nitric oxide-dependent pathways. Alternative splicing of the mRNA for vascular endothelial growth factor A results in several isoforms of the protein being produced.
Concept Schemes:
NALT Full
Entry Terms:
  • glioma-derived vascular endothelial cell growth factor
  • GD-VEGF
  • vasculotropin
  • VEGF-A
  • vascular permeability factor
  • vascular endothelial growth factor-A
URI:
https://lod.nal.usda.gov/nalt/208134
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RDF/XMLCreated 2013-11-15, last modified 2017-11-17