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Preferred Term:

tumor suppressor genes

Genes that inhibit expression of the tumorigenic phenotype. They are normally involved in holding cellular growth in check. When tumor suppressor genes are inactivated or lost, a barrier to normal proliferation is removed and unregulated growth is possible.
Concept Schemes:
Broader Concept:
Entry Terms:
  • metastasis suppressor genes
  • cancer suppressor genes
  • tumour suppressor genes
  • antioncogenes
  • anti-oncogenes
  • tumour suppressing genes
  • tumor suppressing genes
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RDF/XMLCreated 2013-11-13, last modified 2014-02-18