A prion disease found exclusively among the Fore linguistic group natives of the highlands of New Guinea. It is marked by the subacute onset of tremor and ataxia followed by motor weakness and incontinence. The condition is associated with ritual cannibalism, and has become rare since this practice has been discontinued. Pathologic features include a noninflammatory loss of neurons that is most prominent in the cerebellum, glial proliferation, and amyloid plaques.
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