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Preferred Term:

insertional mutagenesis

Definition:
Mutagenesis where the mutation is caused by the introduction of foreign DNA sequences into a gene or extragenic sequence. This may occur spontaneously in vivo or be experimentally induced in vivo or in vitro. Proviral DNA insertions into or adjacent to a cellular proto-oncogene can interrupt genetic translation of the coding sequences or interfere with recognition of regulatory elements and cause unregulated expression of the proto-oncogene resulting in tumor formation.
Concept Schemes:
https://lod.nal.usda.gov/nalt-core
NALT Full
Broader Concept:
URI:
https://lod.nal.usda.gov/nalt/47442
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RDF/XMLCreated 2006-01-19, last modified 2015-05-29