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frameshift mutation

A type of mutation in which a number of nucleotides deleted from or inserted into a protein coding sequence is not divisible by three, thereby causing an alteration in the reading frames of the entire coding sequence downstream of the mutation. These mutations may be induced by certain types of mutagens or may occur spontaneously.
Concept Schemes:
Broader Concept:
Entry Terms:
  • out-of-frame mutation
  • frame shift mutation
  • out-of-frame insertion
  • out-of-frame deletion
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RDF/XMLCreated 2006-01-19, last modified 2017-07-06