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NAL Agricultural Thesaurus
U.S. Department of Agriculture

Concept Breadcrumbs

Research, Technology, Methods > chemical substances > chemical compounds > organic compounds > heterocyclic compounds > actinomycin D
Research, Technology, Methods > drugs > antineoplastic agents > actinomycin D
Research, Technology, Methods > drugs > anti-infective agents > antibiotics > peptide antibiotics > actinomycin D
Research, Technology, Methods > chemical substances > biochemical compounds > amino acids, peptides and proteins > peptides > cyclic peptides > actinomycin D
Fields of Study > biochemistry > biochemical compounds > amino acids, peptides and proteins > peptides > cyclic peptides > actinomycin D
Preferred Term:

actinomycin D

Definition:
A compound composed of a two cyclic peptides attached to a phenoxazine that is derived from Streptomyces parvullus. It binds to DNA and inhibits RNA synthesis (transcription), with chain elongation more sensitive than initiation, termination, or release. As a result of impaired mRNA production, protein synthesis also declines after dactinomycin therapy.
Concept Schemes:
NALT Full
Broader Concept:
heterocyclic compounds, cyclic peptides, antineoplastic agents, peptide antibiotics
Entry Terms:
  • dactinomycin
URI:
https://lod.nal.usda.gov/nalt/3814
Download this Concept:
RDF/XMLCreated 2006-01-19, last modified 2017-11-17