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Concept Breadcrumbs

Preferred Term:

RING finger domains

Definition:
A zinc-binding domain defined by the sequence Cysteine-X2-Cysteine-X(9-39)-Cysteine-X(l-3)-His-X(2-3)-Cysteine-X2-Cysteine -X(4-48)-Cysteine-X2-Cysteine, where X is any amino acid. The RING finger motif binds two atoms of zinc, with each zinc atom ligated tetrahedrally by either four cysteines or three cysteines and a histidine. The motif also forms into a unitary structure with a central cross-brace region and is found in many proteins that are involved in protein-protein interactions. The acronym RING stands for Really Interesting New Gene.
Concept Schemes:
NALT Full
Broader Concept:
Entry Terms:
  • RING finger motifs
  • RING (Really Interesting New Gene) finger domains
URI:
https://lod.nal.usda.gov/nalt/333337
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RDF/XMLCreated 2019-08-26, last modified 2019-11-25