An official website of the United States government.

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

NAL Agricultural Thesaurus
U.S. Department of Agriculture

Concept Breadcrumbs

Research, Technology, Methods > chemical substances > biochemical compounds > enzymes > hydrolases > esterases > nucleases > deoxyribonucleases > endodeoxyribonucleases > CRISPR-associated endonucleases > CRISPR-associated endonuclease 9
Fields of Study > biochemistry > biochemical compounds > enzymes > hydrolases > esterases > nucleases > deoxyribonucleases > endodeoxyribonucleases > CRISPR-associated endonucleases > CRISPR-associated endonuclease 9
Research, Technology, Methods > chemical substances > biochemical compounds > amino acids, peptides and proteins > proteins > CRISPR-associated proteins > CRISPR-associated endonucleases > CRISPR-associated endonuclease 9
Fields of Study > biochemistry > biochemical compounds > amino acids, peptides and proteins > proteins > CRISPR-associated proteins > CRISPR-associated endonucleases > CRISPR-associated endonuclease 9
Preferred Term:

CRISPR-associated endonuclease 9

Definition:
An RNA-guided endodeoxyribonuclease that associates with CRISPR sequences in Streptococcus pyogenes and other bacteria where it participates in an adaptive immune function to cleave foreign DNA complimentary to small guide RNA (sgRNAs). Structurally, Cas9 consists of an alpha-helix module and a nuclease module connected by a single helix. The nuclease module contains two enzymatic domains: RuvC, which cleaves non-target DNA strand, and an HNH nuclease domain, which cleaves the target strand.
Concept Schemes:
NALT Full
Broader Concept:
CRISPR-associated endonucleases
Related Concepts:
Entry Terms:
  • Cas9 protein
  • Cas9 endonuclease
  • Cas9 enzyme
URI:
https://lod.nal.usda.gov/nalt/329081
Download this Concept:
RDF/XMLCreated 2019-03-25, last modified 2019-11-25