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NAL Agricultural Thesaurus
U.S. Department of Agriculture

Concept Breadcrumbs

Research, Technology, Methods > chemical substances > biochemical compounds > amino acids, peptides and proteins > proteins > receptors > lipoprotein receptors > low density lipoprotein receptors
Fields of Study > biochemistry > biochemical compounds > amino acids, peptides and proteins > proteins > receptors > lipoprotein receptors > low density lipoprotein receptors
Research, Technology, Methods > chemical substances > biochemical compounds > amino acids, peptides and proteins > proteins > membrane proteins > lipoprotein receptors > low density lipoprotein receptors
Fields of Study > biochemistry > biochemical compounds > amino acids, peptides and proteins > proteins > membrane proteins > lipoprotein receptors > low density lipoprotein receptors
Preferred Term:

low density lipoprotein receptors

Definition:
Receptors on the plasma membrane of nonhepatic cells that specifically bind LDL. The receptors are localized in specialized regions called coated pits. Hypercholesteremia is caused by an allelic genetic defect of three types: 1, receptors do not bind to LDL; 2, there is reduced binding of LDL; and 3, there is normal binding but no internalization of LDL. In consequence, entry of cholesterol esters into the cell is impaired and the intracellular feedback by cholesterol on 3-hydroxy-3-methylglutaryl CoA reductase is lacking.
Concept Schemes:
NALT Full
Broader Concept:
lipoprotein receptors
Entry Terms:
  • lipoprotein LDL receptors
  • LDL receptors
  • LDL (low density lipoprotein) receptors
URI:
https://lod.nal.usda.gov/nalt/322237
Download this Concept:
RDF/XMLCreated 2018-07-11, last modified 2018-11-14