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NAL Agricultural Thesaurus
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Concept Breadcrumbs

Research, Technology, Methods > chemical substances > biochemical compounds > amino acids, peptides and proteins > proteins > binding proteins > transport proteins > signal transducing adaptor proteins > insulin receptor substrate proteins
Fields of Study > biochemistry > biochemical compounds > amino acids, peptides and proteins > proteins > binding proteins > transport proteins > signal transducing adaptor proteins > insulin receptor substrate proteins
Research, Technology, Methods > chemical substances > biochemical compounds > amino acids, peptides and proteins > proteins > membrane proteins > transport proteins > signal transducing adaptor proteins > insulin receptor substrate proteins
Fields of Study > biochemistry > biochemical compounds > amino acids, peptides and proteins > proteins > membrane proteins > transport proteins > signal transducing adaptor proteins > insulin receptor substrate proteins
Research, Technology, Methods > chemical substances > biochemical compounds > amino acids, peptides and proteins > peptides > intracellular signaling peptides and proteins > signal transducing adaptor proteins > insulin receptor substrate proteins
Fields of Study > biochemistry > biochemical compounds > amino acids, peptides and proteins > peptides > intracellular signaling peptides and proteins > signal transducing adaptor proteins > insulin receptor substrate proteins
Preferred Term:

insulin receptor substrate proteins

Definition:
A structurally-related group of signaling proteins that are phosphorylated by the insulin receptor protein-tyrosine kinase. The proteins share an N-terminal pleckstrin homology domain, a phosphotyrosine-binding domain that interacts with the phosphorylated insulin receptor, and a C-terminal tyrosine-rich domain. Upon tyrosine phosphorylation, insulin receptor substrate proteins interact with specific SH2 domain containing proteins that are involved in insulin receptor signaling.
Concept Schemes:
NALT Full
Broader Concept:
signal transducing adaptor proteins
Related Concepts:
URI:
https://lod.nal.usda.gov/nalt/294108
Download this Concept:
RDF/XMLCreated 2017-03-02, last modified 2017-11-10