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insulin receptor substrate proteins

A structurally-related group of signaling proteins that are phosphorylated by the insulin receptor protein-tyrosine kinase. The proteins share an N-terminal pleckstrin homology domain, a phosphotyrosine-binding domain that interacts with the phosphorylated insulin receptor, and a C-terminal tyrosine-rich domain. Upon tyrosine phosphorylation, insulin receptor substrate proteins interact with specific SH2 domain containing proteins that are involved in insulin receptor signaling.
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RDF/XMLCreated 2017-03-02, last modified 2017-11-10