An official website of the United States government.

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

NAL Agricultural Thesaurus
U.S. Department of Agriculture

Concept Breadcrumbs

Research, Technology, Methods > drugs > antineoplastic agents > etoposide
Research, Technology, Methods > chemical substances > chemical compounds > organic compounds > aromatic compounds > phenolic compounds > lignans > podophyllotoxin > etoposide
Research, Technology, Methods > chemical substances > chemical compounds > organic compounds > aromatic compounds > aromatic hydrocarbons > polycyclic aromatic hydrocarbons > naphthalenes > tetrahydronaphthalenes > podophyllotoxin > etoposide
Research, Technology, Methods > chemical substances > chemical compounds > organic compounds > hydrocarbons > aromatic hydrocarbons > polycyclic aromatic hydrocarbons > naphthalenes > tetrahydronaphthalenes > podophyllotoxin > etoposide
Research, Technology, Methods > chemical substances > chemical compounds > organic compounds > hydrocarbons > polycyclic hydrocarbons > polycyclic aromatic hydrocarbons > naphthalenes > tetrahydronaphthalenes > podophyllotoxin > etoposide
Preferred Term:

etoposide

Definition:
A semisynthetic derivative of podophyllotoxin that exhibits antitumor activity. Etoposide inhibits DNA synthesis by forming a complex with topoisomerase II and DNA. This complex induces breaks in double stranded DNA and prevents repair by topoisomerase II binding. Accumulated breaks in DNA prevent entry into the mitotic phase of cell division, and lead to cell death. Etoposide acts primarily in the G2 and S phases of the cell cycle.
Concept Schemes:
NALT Full
Broader Concept:
podophyllotoxin, antineoplastic agents
Related Concepts:
URI:
https://lod.nal.usda.gov/nalt/262750
Download this Concept:
RDF/XMLCreated 2015-10-07, last modified 2016-02-10