Antimicrobial cationic peptides with a highly conserved amino terminal cathelin-like domain and a more variable carboxy terminal domain. They are initially synthesized as preproproteins and then cleaved. They are expressed in many tissues of humans and localized to epithelial cells. They kill nonviral pathogens by forming pores in membranes.
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RDF/XMLCreated 2015-01-13, last modified 2015-11-16