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NAL Agricultural Thesaurus
U.S. Department of Agriculture

Concept Breadcrumbs

Research, Technology, Methods > chemical substances > biochemical compounds > enzymes > transferases > phosphotransferases (kinases) > protein kinases > protein-tyrosine kinases > receptor protein-tyrosine kinase > erbB-2 receptor
Fields of Study > biochemistry > biochemical compounds > enzymes > transferases > phosphotransferases (kinases) > protein kinases > protein-tyrosine kinases > receptor protein-tyrosine kinase > erbB-2 receptor
Preferred Term:

erbB-2 receptor

Definition:
A cell surface protein-tyrosine kinase receptor that is found to be overexpressed in a significant number of adenocarcinomas. It has extensive homology to and can heterodimerize with the EGF receptor (epidermal growth factor receptor), the erbB-3 receptor and the erbB-4 receptor. Activation of the erbB-2 receptor occurs during heterodimer formation with a ligand-bound erbB receptor family members.
Concept Schemes:
NALT Full
Broader Concept:
receptor protein-tyrosine kinase
Entry Terms:
  • erbB-2 receptor protein-tyrosine kinase
  • proto-oncogene protein HER-2
  • HER-2 proto-oncogene protein
  • human epidermal growth factor receptor-2
  • c-erbB-2 protein
  • neu receptor
  • c-neu proto-oncogene protein
  • erbB-2 proto-oncogene protein
  • proto-oncogene protein c-neu
  • c-erbB2 receptor
  • proto-oncogene proteins c-erbB-2
URI:
https://lod.nal.usda.gov/nalt/222856
Download this Concept:
RDF/XMLCreated 2014-07-25, last modified 2015-12-10