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insulin receptors

A cell surface receptor for insulin. It comprises a tetramer of two alpha and two beta subunits which are derived from cleavage of a single precursor protein. The receptor contains an intrinsic tyrosine kinase domain that is located within the beta subunit. Activation of the receptor by insulin results in numerous metabolic changes including increased uptake of glucose into the liver, muscle, and adipose tissue.
Concept Schemes:
Entry Terms:
  • insulin receptor protein-tyrosine kinase
  • insulin receptor beta subunit
  • insulin-dependent tyrosine protein kinase
  • insulin receptor alpha chain
  • insulin receptor beta chain
  • insulin receptor alpha subunit
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RDF/XMLCreated 2014-07-25, last modified 2017-03-02