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epidermal growth factor receptors

A cell surface receptor involved in regulation of cell growth and differentiation. It is specific for epidermal growth factor and EGF related peptides including transforming growth factor alpha, amphiregulin, and heparin-binding EGF-like growth factor. The binding of ligand to the receptor causes activation of its intrinsic tyrosine kinase activity and rapid internalization of the receptor-ligand complex into the cell.
Concept Schemes:
Entry Terms:
  • erbB-1 proto-oncogene protein
  • EGF receptor
  • epidermal growth factor-urogastrone receptor
  • transforming growth factor alpha receptor
  • c-erbB-1 protein
  • transforming-growth factor alpha receptor
  • transforming growth factor-alpha receptor
  • TGF-alpha receptor
  • epidermal growth factor receptor protein-tyrosine kinase
  • urogastrone receptor
  • EGFR protein
  • epidermal growth factor receptor kinase
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RDF/XMLCreated 2014-07-25, last modified 2014-11-17