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NAL Agricultural Thesaurus
U.S. Department of Agriculture

Concept Breadcrumbs

Fields of Study > immunology > immunologic factors > antigens > surface antigens > differentiation antigens > CD antigens > lymphocyte function-associated antigen-1
Research, Technology, Methods > chemical substances > biochemical compounds > amino acids, peptides and proteins > proteins > membrane proteins > membrane glycoproteins > integrins > lymphocyte function-associated antigen-1
Fields of Study > biochemistry > biochemical compounds > amino acids, peptides and proteins > proteins > membrane proteins > membrane glycoproteins > integrins > lymphocyte function-associated antigen-1
Preferred Term:

lymphocyte function-associated antigen-1

Definition:
An integrin heterodimer widely expressed on cells of hematopoietic origin. CD11A antigen comprises the alpha chain and the CD18 antigen (antigen, CD18) the beta chain. Lymphocyte function-associated antigen-1 is a major receptor of T-cells; B-cells; and granulocytes. It mediates the leukocyte adhesion reactions underlying cytolytic conjugate formation, helper T-cell interactions, and antibody-dependent killing by natural killer cells and granulocytes. Intracellular adhesion molecule-1 has been defined as a ligand for lymphocyte function-associated antigen-1.
Concept Schemes:
NALT Full
Broader Concept:
integrins, CD antigens
Entry Terms:
  • integrin alphaLbeta2
  • leukocyte function associated antigen-1
  • LFA-1 (lymphocyte function-associated antigen-1)
URI:
https://lod.nal.usda.gov/nalt/211305
Download this Concept:
RDF/XMLCreated 2014-02-28, last modified 2017-06-28