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vascular endothelial growth factor receptor-1

A 180-kDa VEGF receptor found primarily in endothelial cells that is essential for vasculogenesis and vascular maintenance. It is also known as Flt-1 (fms-like tyrosine kinase receptor-1). A soluble, alternatively spliced isoform of the receptor may serve as a binding protein that regulates the availability of various ligands for VEGF receptor binding and signal transduction.
Concept Schemes:
Entry Terms:
  • VEGFR-1
  • VEGF receptor flt
  • proto-oncogene protein flt
  • flt1 receptor tyrosine kinase
  • VEGF receptor flt-1 protein
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RDF/XMLCreated 2013-11-15, last modified 2015-04-21