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matrix-assisted laser desorption-ionization mass spectrometry

A mass spectrometric technique that is used for the analysis of large biomolecules. Analyte molecules are embedded in an excess matrix of small organic molecules that show a high resonant absorption at the laser wavelength used. The matrix absorbs the laser energy, thus inducing a soft disintegration of the sample-matrix mixture into free (gas phase) matrix and analyte molecules and molecular ions.
Concept Schemes:
Broader Concept:
Entry Terms:
  • matrix-assisted laser desorption-ionization time-of-flight mass spectrometry
  • SELDI-MS (mass spectrometry)
  • SELDI mass spectrometry
  • MALDI-TOF-MS (mass spectrometry)
  • surface enhanced laser desorption ionization mass spectrometry
  • MALDI mass spectrometry
  • MALDI-MS (mass spectrometry)
  • MALDI-TOF mass spectrometry
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RDF/XMLCreated 2013-11-13, last modified 2018-02-09