Preferred Term:
unfolded protein response
Definition:
A cellular response to environmental insults that cause disruptions in protein folding and/or accumulation of defectively folded protein in the endoplasmic reticulum. It consists of a group of regulatory cascades that are triggered as a response to altered levels of calcium and/or the redox state of the endoplasmic reticulum. Persistent activation of the unfolded protein response leads to the induction of apoptosis.
Concept Schemes:
NALT Full
Broader Concept:
URI:
https://lod.nal.usda.gov/nalt/146596
Download this Concept:
RDF/XMLCreated 2011-08-01, last modified 2017-05-01