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Concept Breadcrumbs

Preferred Term:

gene amplification

Definition:
A selective increase in the number of copies of a gene coding for a specific protein without a proportional increase in other genes. It occurs naturally via the excision of a copy of the repeating sequence from the chromosome and its extrachromosomal replication in a plasmid, or via the production of an RNA transcript of the entire repeating sequence of ribosomal RNA followed by the reverse transcription of the molecule to produce an additional copy of the original DNA sequence.
Concept Schemes:
NALT Core
Broader Concept:
Entry Terms:
  • DNA amplification (in vivo)
  • RNA amplification (in vivo)
URI:
https://lod.nal.usda.gov/nalt/8126
Download this Concept:
RDF/XMLCreated 2006-01-19, last modified 2016-04-04