An official website of the United States government.

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

Concept Breadcrumbs

Preferred Term:

insertional mutagenesis

Definition:
Mutagenesis where the mutation is caused by the introduction of foreign DNA sequences into a gene or extragenic sequence. This may occur spontaneously in vivo or be experimentally induced in vivo or in vitro. Proviral DNA insertions into or adjacent to a cellular proto-oncogene can interrupt genetic translation of the coding sequences or interfere with recognition of regulatory elements and cause unregulated expression of the proto-oncogene resulting in tumor formation.
Concept Schemes:
NALT Core
Broader Concept:
URI:
https://lod.nal.usda.gov/nalt/47442
Download this Concept:
RDF/XMLCreated 2006-01-19, last modified 2015-05-29