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RNA interference

A gene silencing phenomenon whereby specific dsRNAs (RNA, double-stranded) trigger the degradation of homologous mRNA (RNA, messenger). The specific dsRNAs are processed into small interfering RNA (siRNA) which serves as a guide for cleavage of the homologous mRNA in the RNA-induced silencing complex. DNA methylation may also be triggered during this process.
Concept Schemes:
Broader Concept:
Entry Terms:
  • posttranscriptional gene silencing
  • RNA silencing
  • RNAi (RNA interference)
  • RNA interference (RNAi)
  • post-transcriptional gene silencing
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RDF/XMLCreated 2006-01-19, last modified 2016-03-22