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NAL Agricultural Thesaurus and Glossary
U.S. Department of Agriculture

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actinomycin D
Subject Category
H Health and Pathology
S Biological Sciences
W Physical and Chemical Sciences
Definition
A compound composed of a two cyclic peptides attached to a phenoxazine that is derived from Streptomyces parvullus. It binds to DNA and inhibits RNA synthesis (transcription), with chain elongation more sensitive than initiation, termination, or release. As a result of impaired mRNA production, protein synthesis also declines after dactinomycin therapy.
Definition Source
Medical Subject Headings 2011
RDF/XML Format:
http://lod.nal.usda.gov/nalt/3814.rdf
Persistent URI:
http://lod.nal.usda.gov/nalt/3814
Used For
dactinomycin
Broader Term
antineoplastic agents
cyclic peptides
heterocyclic compounds
peptide antibiotics
Spanish
actinomicina D
Term Number
3814