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NAL Agricultural Thesaurus
U.S. Department of Agriculture

Concept Breadcrumbs

Research, Technology, Methods > drugs > antineoplastic agents > etoposide
Research, Technology, Methods > chemical substances > chemical compounds > organic compounds > aromatic compounds > phenolic compounds > lignans > podophyllotoxin > etoposide
Research, Technology, Methods > chemical substances > chemical compounds > organic compounds > aromatic compounds > aromatic hydrocarbons > polycyclic aromatic hydrocarbons > naphthalenes > tetrahydronaphthalenes > podophyllotoxin > etoposide
Research, Technology, Methods > chemical substances > chemical compounds > organic compounds > hydrocarbons > aromatic hydrocarbons > polycyclic aromatic hydrocarbons > naphthalenes > tetrahydronaphthalenes > podophyllotoxin > etoposide
Research, Technology, Methods > chemical substances > chemical compounds > organic compounds > hydrocarbons > polycyclic hydrocarbons > polycyclic aromatic hydrocarbons > naphthalenes > tetrahydronaphthalenes > podophyllotoxin > etoposide
Preferred Term:

etopósido

Definition:
Derivado semisintético de la podofilotoxina que presenta actividad antitumoral. Inhibe la síntesis del ADN mediante la formación de un complejo con la topoisomerasa II y el ADN, que causa rupturas en el ADN bicatenario e impide la reparación por medio de la ligadura de la topoisomerasa II. La acumulación de rupturas en el ADN evita la entrada a la fase mitótica de la división celular y conduce a la muerte celular. El etopósido actúa principalmente en las fases G2 y S del ciclo celular.
Concept Schemes:
https://lod.nal.usda.gov/nalt
Términos Genéricos:
podofilotoxina, agentes antineoplásicos
Términos Relacionados:
URI:
https://lod.nal.usda.gov/nalt/262750
Download this Concept:
RDF/XMLCreated 2015-10-07, last modified 2016-02-10